This comparison is a little different from the others on this page, because FTPie and Mountain Duck aren't really trying to do the same thing.
Mountain Duck takes your cloud storage or FTP server and mounts it as a drive letter in Windows (or a volume on Mac). Once mounted, it shows up in File Explorer just like a USB drive or network share. You can open files, save to it, drag things around — all through the tools you already use. Mountain Duck runs quietly in the background making it happen.
FTPie is a dedicated file manager. You open the app, browse your storages, transfer files between them, preview content, and use built-in tools. It's an active workspace, not a background service.
These are complementary approaches more than competing ones. But if you're deciding which one to get, here's how they actually differ.